Significance of lymphoglandular bodies in bone marrow aspiration smears

✍ Scribed by Robert C. Stern; Katharine Liu; Richard K. Dodge; Kojo S.J. Elenitoba-Johnson; Lester J. Layfield

• Publisher: John Wiley and Sons
• Year: 2001
• Tongue: English
• Weight: 281 KB
• Volume: 24
• Category: Article
• ISSN: 8755-1039
• DOI: 10.1002/dc.1051

✦ Synopsis

Abstract

The presence of lymphoglandular bodies (LGB) or Söderström bodies is often stated to be a feature of lymphoid processes. In our experience, LGB are typically identified in B‐cell processes but not in T‐cell lymphomas or myeloid leukemias. We reviewed 136 bone marrow aspirate smears. The number of LGB per five high‐power fields was counted, and median counts for B‐cell processes, non‐B‐cell processes, myeloid leukemias, and T‐cell malignancies were obtained and compared by the Wilcoxon rank sum test. Bone marrow aspirate smears involved with B‐cell malignancies contained a median of 30 (range, 1–250) LGB per five high‐power fields. Compared to myeloid leukemias (median, 11; range, 1–253) and T‐cell malignancies (median, 7; range, 0–41), the differences were statistically significant (P < 0.001 and P = 0.01, respectively). While lymphoglandular bodies can be seen in a variety of malignant hematopoietic and nonhematopoietic disorders, they are found in significantly greater numbers in B‐cell malignancies. Diagn. Cytopathol. 24:240–243, 2001. © 2001 Wiley‐Liss, Inc.