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Significance of high skin fluxes produced by acyclovir topical formulations for achieving therapeutic levels of drug at the target site in the treatment of cutaneous HSV-1 infections in hairless mice: A closer look at the C* concept: Phenil J. Patel1, Abdel-Halim Ghanem1, William I. Higuchi1, Jer Hsu1, V. Srinivasan2 and Earl R. Kern3. 1Dept. of Pharmaceutics and Pharmaceutical Chemistry, Univ. of Utah, Salt Lake City, UT 84112; 2TheraTech, Inc., 417 Wakara Way, Salt Lake City, UT 84108; 3Dept. of Pediatrics, Univ. of Alabama at Birmingham, AL 35294

Book ID
113259369
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
84 KB
Volume
26
Category
Article
ISSN
0166-3542

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The relationship of basal cell layer dru
The relationship of basal cell layer drug concentration (C*) to the antiviral efficacy: A rigorous evaluation of the C* concept for predicting the entire range of topical efficacy of acyclovir formulations in the treatment of cutaneous HSV-1 infections in hairless mice: Samir C. Mehta, Mohsen I. Afouna, Abdel-Halim Ghanem, William I. Higuchi, Earl R. Kerna and Hamed El-Shattawyb. Dept. of Pharmaceutics and Pharmaceutical Chemistry, Univ. of Utah, Salt Lake City, UT 84112; aDept. of Pediatrics, Univ. of Alabama at Birmingham, AL 35294; bDept. of Pharmaceutics, Univ. of Al-Azhar, Cairo, Egypt
๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 112 KB