Significance and correlations of molecular analysis results in patients with philadelphia chromosome-negative chronic myelogenous leukemia and chronic myelomonocytic leukemia
β Scribed by Hagop M. Kantarjian; Mordechai Shtalrid; Razelle Kurzrock; Marc Buck; Willard T. Dalton; Ann Lemaistre; Sanford A. Stass; Kenneth B. McCredie; Jordan Gutterman; Emil J. Freireich; Moshe Talpaz
- Book ID
- 117014914
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- English
- Weight
- 850 KB
- Volume
- 85
- Category
- Article
- ISSN
- 1555-7162
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π SIMILAR VOLUMES
## Abstract ## BACKGROUND Up to 5% of patients with chronic myelogenous leukemia (CML) do not have the Philadelphia (Ph) translocation t(9;22)(q34;q11) or a __bcr__/__abl__ molecular rearrangement. Although the diagnostic criteria of this entity are still under debate, there is general agreement t
## Abstract ## BACKGROUND Anecdotal cases of chromosomal abnormalities in Philadelphia chromosome (Ph)βnegative metaphases have been reported in patients with chronic myelogenous leukemia (CML) in the chronic phase during treatment with interferon and, more recently, with imatinib. This phenomenon
Background. Five to 10% of patients with chronic myelogenous leukemia (CML) do not have the Philadelphia chromosome (Ph), but one-third of them have rearrangements of the breakpoint cluster region (BCR-positive). Methods. The authors analyzed the characteristics, treatment response, and prognosis o