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Significance and correlations of molecular analysis results in patients with philadelphia chromosome-negative chronic myelogenous leukemia and chronic myelomonocytic leukemia

✍ Scribed by Hagop M. Kantarjian; Mordechai Shtalrid; Razelle Kurzrock; Marc Buck; Willard T. Dalton; Ann Lemaistre; Sanford A. Stass; Kenneth B. McCredie; Jordan Gutterman; Emil J. Freireich; Moshe Talpaz


Book ID
117014914
Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
850 KB
Volume
85
Category
Article
ISSN
1555-7162

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## Abstract ## BACKGROUND Up to 5% of patients with chronic myelogenous leukemia (CML) do not have the Philadelphia (Ph) translocation t(9;22)(q34;q11) or a __bcr__/__abl__ molecular rearrangement. Although the diagnostic criteria of this entity are still under debate, there is general agreement t

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## Abstract ## BACKGROUND Anecdotal cases of chromosomal abnormalities in Philadelphia chromosome (Ph)‐negative metaphases have been reported in patients with chronic myelogenous leukemia (CML) in the chronic phase during treatment with interferon and, more recently, with imatinib. This phenomenon

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✍ Jorge E. Cortes; Moshe Talpaz; Miloslav Beran; Susan M. O'Brien; Mary B. Rios; S πŸ“‚ Article πŸ“… 1995 πŸ› John Wiley and Sons 🌐 English βš– 594 KB

Background. Five to 10% of patients with chronic myelogenous leukemia (CML) do not have the Philadelphia chromosome (Ph), but one-third of them have rearrangements of the breakpoint cluster region (BCR-positive). Methods. The authors analyzed the characteristics, treatment response, and prognosis o