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Signatures of Protein-DNA Recognition in Free DNA Binding Sites

✍ Scribed by Jason W. Locasale; Andrew A. Napoli; Shengfeng Chen; Helen M. Berman; Catherine L. Lawson


Book ID
116664014
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
790 KB
Volume
386
Category
Article
ISSN
0022-2836

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A detailed theoretical analysis of the thermodynamics and functional energetics of protein-DNA binding in the EcoRI endonuclease-DNA complex is presented. The standard free energy of complexation is considered in terms of a thermodynamic cycle of seven distinct steps decomposed into a total of 24 we