## Abstract Central core disease (CCD) is an autosomal‐dominant congenital myopathy, with muscle weakness and malignant hyperthermia (MH) susceptibility. We identified two of nine Brazilian CCD families carrying two mutations in the __RYR1__ gene. The heterozygous parents were clinically asymptomat
✦ LIBER ✦
Signaling to the ribosome in cancer—It is more than just mTORC1
✍ Scribed by Katherine M. Hannan; Elaine Sanij; Nadine Hein; Ross D. Hannan; Richard B. Pearson
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 150 KB
- Volume
- 63
- Category
- Article
- ISSN
- 1521-6543
- DOI
- 10.1002/iub.458
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
Signaling network controlling ribosome synthesis and function by Katherine M. Hannan et al., pp 79–85.
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## Abstract Mutations in __KRAS__ or __BRAF__ frequently manifest in constitutive activation of the MEK1/2‐ERK1/2 signalling pathway. The MEK1/2‐selective inhibitor, AZD6244 (ARRY‐142886), blocks ERK1/2 activation and is currently undergoing clinical evaluation. Tumour cells can vary markedly in th
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