Signaling Through the Cell Matrix

✍ Scribed by Alvaro Macieira-Coelho (auth.), Professor Dr. Alvaro Macieira-Coelho (eds.)

Publisher: Springer Berlin Heidelberg
Year: 2000
Tongue: English
Leaves: 142
Series: Progress in Molecular and Subcellular Biology 25
Category: Library

No coin nor oath required. For personal study only.

✦ Synopsis

This book covers a hot subject in cell biology; i.e. how the cell environment sends messages to the cell, regulates gene expression, and modulates the cell phenotype. For a long time the extracellular matrix was believed to have only a supporting role for cell attachement. However, it became apparent that the matrix participates actively in cell metabolism. The experiments that led to this conclusion are described in this volume. Progressively, molecules have been identified that transmit this signaling at the cell-matrix interface. Their identity and mechanism of action are also illustrated in this book. Finally, it explains the role the cell-matrix relationship plays in the regulation of cell proliferation, cell differentiation, and the expression of malignancy.

✦ Table of Contents

Front Matter....Pages I-X
Topological Constraints Carry Signaling from the Cell Matrix to the Genome....Pages 1-19
The Transmission of Contractility Through Cell Adhesion....Pages 21-35
Role of Focal Adhesion Kinase in Signaling by the Extracellular Matrix....Pages 37-55
Interaction Between Cells and Extracellular Matrix: Signaling by Integrins and the Elastin-Laminin Receptor....Pages 57-70
Regulation of Gene Expression by Changes in Cell Adhesion....Pages 71-87
Expression of Liver Specific-Genes in Hepatocytes Cultured in Collagen Gel Matrix....Pages 89-104
Collagen Type I: A Substrate and a Signal for Invasion....Pages 105-134
Back Matter....Pages 135-136

✦ Subjects

Cell Biology; Cancer Research

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