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Signaling through the Adaptor Molecule MyD88 in CD4+ T Cells Is Required to Overcome Suppression by Regulatory T Cells

✍ Scribed by Schenten, Dominik; Nish, Simone A.; Yu, Shuang; Yan, Xiting; Lee, Heung Kyu; Brodsky, Igor; Pasman, Lesley; Yordy, Brian; Wunderlich, F. Thomas; Brüning, Jens C.; Zhao, Hongyu; Medzhitov, Ruslan


Book ID
122744299
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
96 KB
Volume
40
Category
Article
ISSN
1074-7613

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Signal transduction through cd4 receptor
✍ Jeffrey A. Ledbetter; Carl H. June; Peter S. Rabinovitch; Angelika Grossmann; Th 📂 Article 📅 1988 🏛 John Wiley and Sons 🌐 English ⚖ 892 KB

## Signal transduction through CD4 receptors: stimulatory vs. inhibitory activity is regulated by CD4 proximity to the CD31T cell receptor* The binding of antibody to the CD4 molecule inhibits mobilization of cytoplasmic free calcium ([Ca2'Ii) in response to CD3 cross-linking on resting T cells. S