Signaling through human killer cell activating receptors triggers tyrosine phosphorylation of an associated protein complex

Occupancy of dipeptidyl peptidase IV act

Occupancy of dipeptidyl peptidase IV activates an associated tyrosine kinase and triggers an apoptotic signal in human hepatocarcinoma cells

✍ Lucia Gaetaniello; Michele Fiore; Sergio de Filippo; Nicola Pozzi; Sonia Tamasi; 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 221 KB

Dipeptidyl peptidase IV (CD26/DPP-IV) is an ectoenzyme expressed on different cell types. Signaling properties and functional consequences of the CD26 triggering have been elucidated mostly on T cells, where the molecule delivers a costimulatory signal that potentiates T-cell activation through the