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Signaling pathways of interleukin-1 actions in the brain: Anatomical distribution of phospho-ERK1/2 in the brain of rat treated systemically with interleukin-1β

✍ Scribed by A. Nadjar; C. Combe; P. Busquet; R. Dantzer; P. Parnet

Book ID
116787082
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
584 KB
Volume
134
Category
Article
ISSN
0306-4522

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## Abstract The cytokine interleukin‐1 (IL‐1) is an established and important mediator of diverse forms of neuronal injury in experimental animals. However, its mechanisms of action remain largely unknown. We have reported previously that IL‐1 markedly enhances excitotoxic injury induced in the rat