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Signaling Pathways Involved in Human Vascular Smooth Muscle Cell Proliferation and Matrix Metalloproteinase-2 Expression Induced by Leptin: Inhibitory Effect of Metformin

✍ Scribed by Li, L.; Mamputu, J.-C.; Wiernsperger, N.; Renier, G.

Book ID
127176972
Publisher
American Diabetes Association
Year
2005
Tongue
English
Weight
186 KB
Volume
54
Category
Article
ISSN
0012-1797

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## Abstract The expression of matrix metalloproteinase‐9 (MMP‐9) has been implicated in progression of atherosclerotic lesions. The role and importance of the signaling pathway in the transcriptional regulation of MMP‐9 in human aortic smooth muscle cells (HASMC) was examined. Tumor necrosis factor