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Signaling pathways in chronic myeloid leukemia and leukemic stem cell maintenance: Key role of stromal microenvironment

✍ Scribed by P.F. Seke Etet; L. Vecchio; A.H. Nwabo Kamdje


Book ID
111887180
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
451 KB
Volume
24
Category
Article
ISSN
0898-6568

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## Abstract Chronic Myeloid Leukemia (CML), a myeloproliferative disease of stem cell origin, is characterized by the presence of the Philadelphia (Ph) chromosome and the __bcr‐abl__ oncogene. The BCR‐ABL fusion gene product, thought to be causative in CML, has multiple effects on diverse cell func