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Signaling pathways implicated in α-melanocyte stimulating hormone-induced lipolysis in 3T3-L1 adipocytes

✍ Scribed by Kyung-Joo Cho; Jung-Hyun Shim; Min-Chul Cho; Yong-Kyung Choe; Jin-Tae Hong; Dong-Chul Moon; Jong-Wan Kim; Do-Young Yoon

Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
228 KB
Volume
96
Category
Article
ISSN
0730-2312

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✦ Synopsis

Abstract

Melanocortins, besides their central roles, have also recently been reported to regulate adipocyte metabolism. In this study, we attempted to characterize the mechanism underlying α‐melanocyte‐stimulating hormone (MSH)‐induced lipolysis, and compared it with that of the adrenocorticotrophin hormone (ACTH) in 3T3‐L1 adipocytes. Similar to ACTH, MSH treatment resulted in the release of glycerol into the cell supernatant. The activity of hormone‐sensitive lipase, a rate‐limiting enzyme, which is involved in lipolysis, was significantly increased by MSH treatment. In addition, a variety of kinases, including protein kinase A (PKA) and extracellular signal‐regulated kinase (ERK) were also phosphorylated as the result of MSH treatment, and their specific inhibitors caused a reduction in MSH‐induced glycerol release and HSL activity, indicating that MSH‐induced lipolysis was mediated by these kinases. These results suggest that PKA and ERK constitute the principal signaling pathways implicated in the MSH‐induced lipolytic process via the regulation of HSL in 3T3‐L1 adipocytes. J. Cell. Biochem. © 2005 Wiley‐Liss, Inc.

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