Signaling mechanisms regulating T cell diversity and function

✍ Scribed by Kappes, Dietmar; Soboloff, Jonathan

Publisher: CRC Press, Taylor & Francis
Year: 2017
Tongue: English
Leaves: 274
Series: Methods in Signal Transduction Series
Edition: 1
Category: Library

No coin nor oath required. For personal study only.

✦ Synopsis

T cells play a vital role mediating adaptive immunity, a specific acquired resistance to an infectious agent produced by the introduction of an antigen. There are a variety of T cell types with different functions. They are called T cells, because they are derived from the thymus gland. This volume discusses how T cells are regulated through the operation of signaling mechanisms. Topics covered include positive and negative selection, early events in T cell receptor engagement, and various T cell subsets.

✦ Table of Contents

Content: Consequences of blocking the choreography of double negative thymocyte maturation / John Barnet --
In situ analysis of T cell receptor signals during positive selection / Nathalie Labrecque, Mengqi Dong, Aditi Sood, and Heather J. Melichar --
Regulation of negative selection in the thymus by cytokines : novel role of IL-23 to regulate ROR[gamma]t / John D. Mountz, Robert Lowe, Hao Li, and Hui-Chen Hsu --
Modulating thymic negative selection with bioengineered thymus organoids / Massimo Trucco, Isha Pradhan, Asako Tajima, Suzanne Bertera, and Yong Fan --
Characterizing the role of ThPok in cd4/cd8 selection / Dietmar Kappes --
TCR signaling circuits in a[beta]/d[gamma] T lineage choice / David Wiest, Shawn P. Fahl, and Dietmar J. Kappes --
Phenotypic and functional characterization of regulatory T cell populations / Talal Chatila and Louis-Marie Charbonnier --
T cell factor 1, mTOR and NKT development / Jyoti Sen, Nicola M. Heller, Rosa Berga-Bolanos, and Lynette Naler --
Transmission of T cell receptor-mediated signaling via the GRB2 family of adaptor proteins / Jon C.D. Houtman and Mahmood Y. Bilal --
Defining the roles of Ca2+ signals during T cell activation / Elsie Samakai, Christina Go, and Jonathan Soboloff --
Histone methyltransferases and T cell heterogeneity / Janaki Purushe and Yi Zhang --
Models of regulatory T cell alterations and systemic autoimmunity / Jonathan Cho, Dorina Avram, and Kyle J. Lorentsen.

✦ Subjects

T-Lymphocytes;immunology;Receptors, Antigen, T-Cell;immunology;TCF Transcription Factors;Signal Transduction;Thymus Gland;secretion;T cells

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