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Signaling mechanisms, interaction partners, and target genes of STAT6

✍ Scribed by Daniel Hebenstreit; Gerald Wirnsberger; Jutta Horejs-Hoeck; Albert Duschl

Book ID
116401012
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
395 KB
Volume
17
Category
Article
ISSN
1359-6101

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The STAT proteins (signal transducers and activators of transcription) are transcription factors mediating cytokine/growth factor signaling, which play important role in controlling cell cycle progression and apoptosis. In many cancer cell lines and tumors (including gliomas) the STAT proteins (in p