Signal transduction through the T cell receptor is dynamically regulated by balancing kinase and phosphatase activities
โ Scribed by Andrew E Schade; Alan D Levine
- Book ID
- 117052392
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 318 KB
- Volume
- 296
- Category
- Article
- ISSN
- 0006-291X
No coin nor oath required. For personal study only.
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## Signal transduction through CD4 receptors: stimulatory vs. inhibitory activity is regulated by CD4 proximity to the CD31T cell receptor* The binding of antibody to the CD4 molecule inhibits mobilization of cytoplasmic free calcium ([Ca2'Ii) in response to CD3 cross-linking on resting T cells. S
The expression and function of discoidin domain receptor 1 (DDR1) in T cells are still poorly explored. We have recently shown that activation of primary human T cells via their T cell receptor leads to increased expression of DDR1, which promoted their migration in three-dimensional collagen. In th