Signal transduction-related gene transfer leads to inhibition of proliferation and induction of differentiation in laryngeal squamous cell carcinoma in vitro

Apoptosis-promoting gene (bax) transfer

Apoptosis-promoting gene (bax) transfer potentiates sensitivity of squamous cell carcinoma to cisplatin In vitro and In vivo

✍ Chizuru Sugimoto; Shigeharu Fujieda; Mizue Seki; Hiroshi Sunaga; Guo-Kang Fan; H 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 French ⚖ 638 KB

Modulation of apoptosis may potentiate the sensitivity of tumor cells to chemotherapeutic agents, thus improving the clinical outcome of cancer treatment. Bax, an apoptosispromoting member of the bcl-2 family, may be a key factor influencing the chemosensitivity of tumor cells, however, its involvem