Signal Transduction of Mechanical Stimuli Is Dependent on Microfilament Integrity: Identification of Osteopontin as a Mechanically Induced Gene in Osteoblasts

Osteoblasts induce osteopontin expressio

Osteoblasts induce osteopontin expression in response to attachment on fibronectin: Demonstration of a common role for integrin receptors in the signal transduction processes of cell attachment and mechanical stimulation

✍ R.S. Carvalho; J.L. Schaffer; L.C. Gerstenfeld 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 230 KB 👁 3 views

Osteopontin is a predominant integrin binding protein of bone and its expression has been shown to be induced by mechanical stimuli within osteoblasts J. Bone Miner. Res. 12:1626Res. 12: -1636)). The present studies examined if the cell adhesion would mimic the mechano-transduction that stimulated