SIGNAL TRANSDUCTION IN Th CLONES: TARGET OF DIFFERENTIAL MODULATION BY PGE2MAY RESIDE DOWNSTREAM OF THE PKC-DEPENDENT PATHWAY

PKC-MEK-MAPK-dependent signal transducti

PKC-MEK-MAPK-dependent signal transduction pathway mediates the stimulation of lysyl oxidase expression by serum and PDGF in rat aortic smooth muscle cells

✍ Lynda Smith-Mungo; Herbert M. Kagan 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 222 KB

## Abstract Lysyl oxidase (LO) plays a critical role in the stabilization and insolubilization of fibrous structural proteins of the extracellular matrix and has been implicated in the suppression of Ras‐induced tumorigenesis. Several prior reports demonstrate that the expression of this catalyst i