✦ LIBER ✦

Signal transduction in Sjögren's syndrome T cells. Abnormalities associated with a newly described human A-type retrovirus

✍ Scribed by Eliezer Flescher; Michael J. Dauphinée; Donna Fossum; Jeffrey Ledbetter; Norman Talal

Publisher: John Wiley and Sons
Year: 1992
Tongue: English
Weight: 619 KB
Volume: 35
Category: Article
ISSN: 0004-3591
DOI: 10.1002/art.1780350912

No coin nor oath required. For personal study only.

✦ Synopsis

Objective. To study the effects of a novel A-type retrovirus, detected in cocultures of lip biopsy specimens from Sjogren's syndrome (SS) patients and a human T cell line, on the infected T cells.

Methods. Interleukin-2 (IL-2) and IL-6 secretion were measured by bioassay and enzyme-linked immunosorbent assay, respectively, in the infected and noninfected cell lines. Surface antigen expression was determined by flow cytometry, using monoclonal antibodies. Protein kinase C (PKC) activity was measured using an enzyme assay kit, and calcium mobilization was assessed with a fluorescent probe.

Results.

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## Objective. To clarify the involvement of human T lymphotropic virus type I (HTLV-I) in the pathogenesis of Sjogren's syndrome (SS). Methods. In HTLV-I-seropositive patients with SS, HTLV-I proviral DNA in the labial salivary glands (SG) was detected by polymerase chain reaction (PCR) amplificat