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Signal transduction by p21ras

✍ Scribed by C. J. Marshall; A. C. Lloyd; J. D. H. Morris; H. Paterson; B. Price; A. Hall

Publisher
John Wiley and Sons
Year
1989
Tongue
French
Weight
405 KB
Volume
44
Category
Article
ISSN
0020-7136

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✦ Synopsis

Experiments using the physical loading of purified recombinant p2 I ras proteins into quiescent normal cells to analyze how the proteins stimulate DNA synthesis and morphological transformation are reviewed. The results indicate that oncogenic p2 I ras proteins rapidly activate a protein-kinase-C-dependent pathway and a proteinkinase-C-independent pathway. The activation of protein kinase C is absolutely required for p2I ras to stimulate DNA synthesis but is not required for morphological transformation.

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