It has previously been shown that nerve growth factor (NGF) is of functional significance for mature pig oligodendrocytes (OLs) in culture. The present data give evidence for the expression of TrkA, the so-called high-affinity NGF receptor, and of p75NTR, the socalled low-affinity NGF receptor. TrkA
Signal transduction and transcription factors in rheumatic disease
β Scribed by Gary S. Firestein; Anthony M. Manning
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 279 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0004-3591
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
The members of the neurotrophin family play key biological roles in the development of the nervous system. Based on studies initially in cell lines (e.g., the rat pheochromocytoma PC12 cells), neurotrophins have been found to be important mediators of proliferation, differentiation, and survival in
The lactate dehydrogenase-A (LDH-A) gene, whose product plays a pivotal role in normal anaerobic glycolysis and is frequently increased in human cancers, is highly regulated at the transcriptional and posttranscriptional levels. Our laboratory has carried out extensive studies concerning the regulat
Background. Favorable neuroblastomas frequently express high levels of the TrkA receptor, and these tumors have a propensity to either differentiate or regress, but the mechanisms responsible for these two fates are unclear. Procedure. To study TrkA signal transduction in neuroblastoma (nb), we stab