✦ LIBER ✦

Sideroblastic anemia terminating in myelofibrosis

✍ Scribed by Dr. Daniel F. Lukowicz; Thomas J. Myers; Joseph A. Grasso; Maurice M. Albala

Publisher: John Wiley and Sons
Year: 1982
Tongue: English
Weight: 753 KB
Volume: 13
Category: Article
ISSN: 0361-8609
DOI: 10.1002/ajh.2830130309

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Two patients with primary acquired sideroblastic anemia who eventually developed myelofibrosis with myeloid metaplasia are reported. Splenectomy was performed in one patient because of increasing blood transfusion requirements, and splenic histology revealed both myeloid metaplasia and ringed sideroblasts. The second patient showed a partial response of the sideroblastic anemia to pyridoxine therapy during the early stages of development of the myelofibrosis. Myelofibrosis with myeloid metaplasia may represent a nonspecific response of the marrow tissue to sideroblastic anemia as to other primary hematologic disorders.

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