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Side reactions in the pyroglutamic acid-7-amino-4-methylcoumarin synthesis

✍ Scribed by ZICANE, DANA ;PETROVA, MARINA ;TETERE, ZENTA ;KREISHMAN, GEORGE ;BROOKS, ELWOOD ;KARLSON, JAMES ;KALEJS, UDO


Book ID
115099937
Publisher
Wiley (Blackwell Publishing)
Year
2009
Tongue
English
Weight
294 KB
Volume
48
Category
Article
ISSN
0367-8377

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Pyroglutamic Acid in Drug Synthesis, Par
✍ Wilhelm Fleischhacker; Thomas Riedl; Horst VΓΆllenkle; Christian R. Noe πŸ“‚ Article πŸ“… 1996 πŸ› John Wiley and Sons 🌐 English βš– 871 KB

Synthesis of the title compounds is described, starting from alkylation of the pyroglutaminol-acetal 4a"' at the a-lactam position C-6 with methyl iodide. Subsequent addition of 2-cyclohexen-lone led to diastereoselective formation of the 1.2-aldol addition product 7 W c , which after dehydratizatio