✦ LIBER ✦
Side chain modified sterols as probes into insect molting hormone metabolism. I: synthesis of monofluorophytosterols
✍ Scribed by Toni B. Kline; Glenn D. Prestwich
- Book ID
- 104220999
- Publisher
- Elsevier Science
- Year
- 1982
- Tongue
- French
- Weight
- 233 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
✦ Synopsis
25-and 26-monofluorophytosterols were synthesized from stigmasterol as potential arthropod-activated competitive inhibitors of side chain hydroxylations occurring in ecdysone biogenesis. An attractive biosynthetic pathway for the design of arthropod-selective control agents is the conversion of dietary C28 and C2g sterols via cholesterol to the ecdysteroid molting hormones. This requires dealkylation at C-24, several oxidative steps in the sterol nucleus, and finally hydroxylation at C-20,
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