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Side-chain and backbone flexibility in protein core design

✍ Scribed by John R. Desjarlais; Tracy M. Handel


Book ID
115629411
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
386 KB
Volume
290
Category
Article
ISSN
0022-2836

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✍ Rafael Najmanovich; Josef Kuttner; Vladimir Sobolev; Marvin Edelman πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 English βš– 122 KB πŸ‘ 1 views

Ligand binding may involve a wide range of structural changes in the receptor protein, from hinge movement of entire domains to small side-chain rearrangements in the binding pocket residues. The analysis of side chain flexibility gives insights valuable to improve docking algorithms and can provide