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Sickle cell anemia and trait in a population of southern india

✍ Scribed by Gary Brittenham; B. Lozoff; J. W. Harris; V. S. Sharma; S. Narasimhan

Publisher: John Wiley and Sons
Year: 1977
Tongue: English
Weight: 500 KB
Volume: 2
Category: Article
ISSN: 0361-8609
DOI: 10.1002/ajh.2830020104

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

In an ethnic group in southern India, the Irula, seven individuals with sickle cell anemia were found to manifest only mild illness. Although a relatively high level of fetal hemoglobin was present in one, none of the factors thought to ameliorate the course of sickling disorders could be identified in the remaining six. In a random population survey, sickle hemoglobin was found in 90 of 292 Irula (31%). In those with sickle cell trait, the proportion of sickle hemoglobin in hemolysates (mean = 26%, range 19–32%) was substantially lower than that reported for any other population.

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