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Sibs of probands with neural tube defects —A study in the Federal Republic of Germany

✍ Scribed by Manuela Koch; W. Fuhrmann

Publisher: Springer
Year: 1985
Tongue: English
Weight: 558 KB
Volume: 70
Category: Article
ISSN: 0340-6717
DOI: 10.1007/bf00389463

No coin nor oath required. For personal study only.

✦ Synopsis

Data for the risk of neural tube defects in sibs of affected children are needed for genetic counselling, for decision on prenatal studies, and for planning of preventive measures. Data have been reported from various populations but were lacking for Germany. This study presents data on the siblings of 240 index patients in the Western part of the Federal Republic of Germany. The prevalence among sibs of affected individuals was found to be 2.6%. This figure agrees well with reports from other countries in Continental Europe and the United States, and fits the expectation of lower recurrence risks in low incidence populations.

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