Sialylated Lea blood group substances detected by the monoclonal antibody Ca 19-9 in human seminal plasma and other organs
✍ Scribed by Uhlenbruck, G. ;Höller, U. ;Heising, J. ;van Mil, A. ;Dienst, C.
- Publisher
- Springer
- Year
- 1985
- Tongue
- English
- Weight
- 335 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0300-5623
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✦ Synopsis
The glycoprotein fractions of human seminal plasma, amniotic fluid, urine, human saliva and human gastric juice have been found to contain sialyl-Lea blood group substance, an antigen and which is known to function as a tumor-marker in human pancreatic and gastrointestinal cancer (Ca 19-9). Tumor-associated carbohydrate structures may well occur in large amounts both in normal tissue and in secretions as organ-specific markers. In human seminal plasma typical variations have been found in relationship to the Lewis blood group of the donor. Accordingly, the Ca 19-9 antigen can be regarded as a marker of the main glycoprotein fraction of human seminal plasma, which could be useful as a tool for clinical investigations.