Sialoside-binding macrophage lectins in phagocytosis of apoptotic bodies
✍ Scribed by E. M. Rapoport; Yu. B. Sapot’ko; G. V. Pazynina; V. K. Bojenko; N. V. Bovin
- Publisher
- Springer
- Year
- 2005
- Tongue
- English
- Weight
- 119 KB
- Volume
- 70
- Category
- Article
- ISSN
- 0006-2979
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Hepatic stellate cell activation is a main feature of liver fibrogenesis. We have previously shown that phagocytosis of apoptotic bodies by stellate cells induces procollagen ␣1 (I) and transforming growth factor beta (TGF-) expression in vitro. Here we have further investigated the downstream effe
## Abstract ## Objective Phagocytosis of apoptotic cells can be facilitated by complement components and short pentraxins, such as serum amyloid P (SAP). In contrast, the long pentraxin PTX3 was shown to inhibit phagocytosis of apoptotic Jurkat cells by dendritic cells and to bind late apoptotic p