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Sialic Acid and Structural Analogues: Stereoselective Syntheses
โ Scribed by Ivan Hemeon; Andrew J. Bennet
- Publisher
- John Wiley and Sons
- Year
- 2007
- Weight
- 11 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0931-7597
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๐ SIMILAR VOLUMES
A total synthesis of the optically active tetrahydroesterastinB -1actam analogue 2 using MilZer's hydroxamate approach is described (Scheme 2). Significant modification of published procedures has resulted in a short and facile stereospecific preparation of the N-[(benzyloxycarbonyl)methyl]$ -1actam
The conjugate addition of benzylamine to three polyalkoxy a,benones derived from d-glyceraldehyde, d-erythrose, and d-mannose, whose carbonyls were flanked by the thiazole ring, proceeded with modest to good synselectivity. The resulting polyalkoxy bamino ketones were converted by ketalization into
## Abstract 2โDeoxyโ2โH~eq~โ__N__โacetylneuraminic acid (1a) has been shown to be a versatile mimic for sialosyl 2โฮฑโglycosides to study the hemagglutininโsialic acid interaction. Starting with a 4โoxo derivative of 2โdeoxyโ2โH~eq~โsialic acid, we obtained the 4โ__C__โmethyl~ax~ and 4โ__C__โmethyl~