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Shrinkage estimation in two-stage adaptive designs with midtrial treatment selection

✍ Scribed by Máximo Carreras; Werner Brannath

Book ID
112207162
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
316 KB
Volume
32
Category
Article
ISSN
0277-6715

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✍ Ionut Bebu; George Luta; Vladimir Dragalin 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 144 KB 👁 2 views

## Abstract A conditional likelihood‐based approach is proposed to construct confidence intervals for the parameters of interest in a two‐stage design with treatment selection after the first stage. Both a Wald confidence interval and a confidence interval based on inverting the likelihood ratio te