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SHPS-1/SIRP1α contributes to interleukin-6 signalling

✍ Scribed by Radoslaw M. Sobota; Pia J. Müller; Christina Khouri; Axel Ullrich; Valeria Poli; Tetsuya Noguchi; Peter C. Heinrich; Fred Schaper

Book ID
113528191
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
813 KB
Volume
20
Category
Article
ISSN
0898-6568

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## Abstract The substrate specificity of catalytic domains and the activation of full length protein tyrosine phosphatases, SHP‐1 and SHP‐2 have been investigated using synthetic phosphotyrosyl peptides derived from SIPRα1. We found that the catalytic domains of SHP‐1 and SHP‐2 exhibit different su