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SHPS-1 regulates integrin-mediated cytoskeletal reorganization and cell motility

✍ Scribed by Inagaki, K.

Book ID: 111747708
Publisher: Nature Publishing Group
Year: 2000
Tongue: English
Weight: 385 KB
Volume: 19
Category: Article
ISSN: 0261-4189
DOI: 10.1093/emboj/19.24.6721

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## Abstract α4β1 integrin is highly expressed in lymphocytes and is essential in hematopoiesis, extravasation, and the inflammatory response. α4β1 can be activated by intracellular signals elicited upon T‐cell activation by phorbol esters, CD3 crosslinking, or certain chemokine/receptor interaction