Should platelets be radiolabelled in plasma medium?

✍ Scribed by Min-Fu Tsan; Robin L. Hill-Zobel

• Book ID: 101436696
• Publisher: John Wiley and Sons
• Year: 1987
• Tongue: English
• Weight: 325 KB
• Volume: 25
• Category: Article
• ISSN: 0361-8609
• DOI: 10.1002/ajh.2830250318

✦ Synopsis

Because of the low labelling efficiency of platelets with In-111 oxine in plasma containing media, most investigators have labelled platelets in plasma-free media. However, labelling of platelets with In-111 oxine in plasma-free media may result in either: 1) irreversible damage leading to rapid clearance from the circulation and permanent hepatic sequestration; or 2) reversible damage with transient hepatic sequestration without affecting the in vivo survival. Since human platelets can be labelled with In-111 oxine in plasma in sufficient efficiency for routine clinical use, they should be labelled in plasma whenever possible. The use of newer In-111 chelates, tropolone and mercaptopyridine-N-oxide, which label platelets with high efficiency in plasma as well as in plasma-free media, may offer another alternative.