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Shotgun analysis of membrane proteomes using a novel combinative strategy of solution-based sample preparation coupled with liquid chromatography–tandem mass spectrometry

✍ Scribed by Yong Lin; Hui Liu; Zhonghua Liu; Xianchun Wang; Songping Liang

Book ID: 116620800
Publisher: Elsevier Science
Year: 2012
Tongue: English
Weight: 552 KB
Volume: 901
Category: Article
ISSN: 1873-376X
DOI: 10.1016/j.jchromb.2012.05.035

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## Abstract A liquid chromatographic/tandem mass spectrometric (LC/MS/MS) assay for the quantitative analysis of the novel anticancer drug ABT‐518 and the screening of six potential metabolites in human plasma has been developed and validated to support a phase I study with the drug. ABT‐518 is an