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Short/long heterozygotes at 5HTTLPR and white matter lesions in geriatric depression

✍ Scribed by David C. Steffens; Warren D. Taylor; Douglas R. McQuoid; K. Ranga R. Krishnan

Publisher: John Wiley and Sons
Year: 2008
Tongue: English
Weight: 64 KB
Volume: 23
Category: Article
ISSN: 0885-6230
DOI: 10.1002/gps.1869

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Objective

We examined the relationship between 5HTTLPR genotype and volume of magnetic resonance imaging (MRI) brain lesions.

Method

We studied 217 older depressed patients and 141 individuals in the comparison group using a standard brain MRI protocol to calculate lesion volumes. Genotype at 5HTTLPR was determined for each subject.

Results

In age‐adjusted models, the l/s genotype was associated with increased volume of total and white‐matter lesions among depressed patients. This relationship lost significance in models controlling for reported hypertension.

Conclusions

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