Shorter survival in HIV-positive patients with diarrhoea who excrete adenovirus from the GI tract
✍ Scribed by Sabin, Caroline A.; Clewley, Gillian S.; Deayton, Jane R.; Mocroft, Amanda; Johnson, Margaret A.; Lee, Christine A.; McLaughlin, James E.; Griffiths, Paul D.
- Book ID
- 101216976
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 85 KB
- Volume
- 58
- Category
- Article
- ISSN
- 0146-6615
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✦ Synopsis
Adenoviruses have been described as a cause of diarrhoea in patients infected with the human immunodeficiency virus (HIV). The prevalence of adenoviruses was studied in all HIV-positive patients presenting with diarrhoea at the Royal Free Hospital in London between 1991 and 1995. In addition, all postmortems carried out in HIVpositive individuals registered at the same centre between 1990 and 1997 were reviewed for evidence of adenovirus infection. Adenovirus was detected in 16.1% of patients presenting with diarrhoea. These individuals had a significantly lower CD4 count and were more likely to have had a diagnosis of acquired immunodeficiency syndrome (AIDS) than patients with diarrhoea in whom adenovirus was not detected. The median survival was 1 year compared with 2.4 years for those without adenoviruses; this difference remained significant (P = .008) after controlling for differences in CD4 counts between the groups. Gastrointestinal adenovirus excretion occurs at an advanced stage of HIV disease, and is associated with a poor prognosis. We suggest that adenoviruses may contribute to mortality in this population.