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Short-term stability of HIV provirus levels in the peripheral blood of HIV-infected individuals

✍ Scribed by David B. Paul; Mary C. Kuhns; Anne L. McNamara; John C. Pottage Jr.; Gregory T. Spear

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
632 KB
Volume
47
Category
Article
ISSN
0146-6615

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✦ Synopsis

Abstract

Changes in viral load have been reported to reflect disease progression or response to therapy; however, the stability of HIV DNA levels in HIV infected individuals has not been extensively studied. Cellular HIV DNA levels in infected individuals were evaluated over a short time period to determine degree of variability as well as any correlation with other measurements of virus load or immune status. Peripheral blood mononuclear cells (PBMC) were obtained several times over 1 month from 32 asymptomatic or symptomatic non‐AIDS, HIV‐infected individuals currently on AZT therapy. PCR amplification of the HIV gag region was performed with DNA from PBMC lysates and the PCR amplified products quantitated by liquid phase hybridization. HIV DNA levels in the majority of the patients were relatively stable, with 26 of 32 persons having less than threefold change. Changes over the study period were both positive and negative, and the median change in HIV DNA levels was 68.6%. These changes were found to positively correlate with fluctuations in plasma p24 levels. In contrast, no correlations were found with other measurements of immune system activity, including changes in CD4 number, CD4 percent, and p, ‐microglobulin when compared with provirus changes. This study shows that levels of HIV DNA can be relatively stable over short periods in most non‐AIDS, HIV‐infected persons. © Wiley‐Liss, Inc.

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