Short term exposure to elevated levels of leptin reduces proximal tubule cell metabolic activity

Prostate carcinoma cells selected by lon

Prostate carcinoma cells selected by long-term exposure to reduced oxygen tension show remarkable biochemical plasticity via modulation of superoxide, HIF-1α levels, and energy metabolism

✍ Jeanne Bourdeau-Heller; Terry D. Oberley 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 425 KB

## Abstract Cancer cells are able to tolerate levels of O~2~ that are damaging or lethal to normal cells; we hypothesize that this tolerance is the result of biochemical plasticity which maintains cellular homeostasis of both energy levels and oxidation state. In order to examine this hypothesis, w