Short-term effects of 3,5,3′–triiodothyronine on the activity of selected enzymes of intermediary metabolism in the liver of the Atlantic hagfish,Myxine glutinosa
✍ Scribed by Leary, S. C.; Reddy, K.; Battersby, B. J.; Dugan, S.; Ballantyne, J. S.
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 68 KB
- Volume
- 278
- Category
- Article
- ISSN
- 0022-104X
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✦ Synopsis
The short-term effects of 3,5,3´-triiodothyronine (T 3 ) on the intermediary metabolism of the liver of the Atlantic hagfish (Myxine glutinosa) were assessed by intraperitoneal injection of T 3 . Three hours postinjection, plasma T 3 concentrations and the activities of key enzymes involved in glycolysis, lipid catabolism, and amino acid and oxidative metabolism were measured. Plasma T 3 levels were significantly higher (P < 0.05) in T 3 -treated fish when compared to control and pretreatment fish. T 3 -treated fish had significantly higher (P < 0.05) activity of a pentose phosphate shunt enzyme, glucose-6-phosphate dehydrogenase, than control fish. The activity of an enzyme of lipid catabolism, carnitine palmitoyl transferase, increased significantly (P < 0.05) above that of the controls in fish treated with a low T 3 dose. Other enzymes of amino acid metabolism and oxidative metabolism were not affected by T 3 treatment. In the shortterm, T 3 may modulate intermediary metabolism in the liver by increasing the catabolism of lipids to supply the energy requirements of biosynthetic processes.