Short step enantioselective synthesis of (−)-swainsonine

✍ Scribed by T. Punniyamurthy; Ryo Irie; Tsutomu Katsuki

• Publisher: John Wiley and Sons
• Year: 2000
• Tongue: English
• Weight: 164 KB
• Volume: 12
• Category: Article
• ISSN: 0899-0042
• DOI: 10.1002/(sici)1520-636x(2000)12:5/6<464::aid-chir28>3.0.co;2-z

✦ Synopsis

Recent discovery of asymmetric desymmetrization of meso-heterocycles using (R,R)-(salen)manganese complex 2 as a catalyst allowed easy access to optically active 2,3,4-trisubstituted pyrrolidines. Taking advantage of this new reaction, we could achieve the short-step synthesis of (-)-swainsonine 1.