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Short interfering RNA-directed inhibition of hepatitis B virus replication

โœ Scribed by Keisuke Hamasaki; Kazuhiko Nakao; Kojiro Matsumoto; Tatsuki Ichikawa; Hiroki Ishikawa; Katsumi Eguchi


Book ID
117105367
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
141 KB
Volume
543
Category
Article
ISSN
0014-5793

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To develop synthetic short interfering RNA (siRNA) molecules as therapeutic agents for systemic administration in vivo, chemical modifications were introduced into siRNAs targeted to conserved sites in hepatitis B virus (HBV) RNA. These modifications conferred significantly prolonged stability in hu