SHORT COMMUNICATIONPhotodynamic therapy with delta-aminolaevulinic acid for nodular basal cell carcinomas using a prior debulking technique
✍ Scribed by M.R.T.M. Thissen; C.A. Schroeter; H.A.M. Neumann
- Book ID
- 104459406
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 157 KB
- Volume
- 142
- Category
- Article
- ISSN
- 0007-0963
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✦ Synopsis
The incidence of basal cell carcinomas (BCCs) is still increasing, and there is a demand for an easy, effective and selective non-invasive treatment such as topical photodynamic therapy (PDT). Twenty-three patients with 24 nodular BCCs were treated once with delta-aminolaevulinic acid (delta-ALA) PDT (100 mW cm(-2), 120 J/cm2) 3 weeks after prior debulking of the BCCs. Three months after PDT, all lesions were surgically excised and histopathologically evaluated for residual tumour. Twenty-two (92%) of the 24 nodular BCCs showed a complete response on clinical and histopathological examination. PDT for superficially abraded nodular BCCs with topically applied delta-ALA and the VersaLight as light source is an easy, effective and safe therapy, with excellent cosmetic results and no serious side-effects, in cases where non-surgical treatment of BCCs is indicated.