✍ Scribed by M. B. Roure; A. M. Lambert; C. Cour; P. Bonnet; A. M. Saillenfait
No coin nor oath required. For personal study only.
Male Sprague-Dawley rats were administered a single intraperitoneal injection of N , N-dimethylformamide (DMF, 0.01-1.5 g kg-I) or were exposed for 4 h to DMF vapours (75-900 ppm). The serum activities of the enzymes sorbitol deshydrogenase and glutamate deshydrogenase were used as indicators of liver damage, and were determined at 24, 48 or 72 h post-treatment.
Following either route of administration DMF caused concentration-dependent elevations in enzyme activities, the maxima of which occurred later after administration of higher concentrations of DMF than after lower concentrations.
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