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Short- and long-term regulation of 3-hydroxy 3-methylglutaryl coenzyme A reductase by a 4-methylcoumarin

✍ Scribed by Laura Trapani; Marco Segatto; Veronica Simeoni; Valentina Balducci; Ashish Dhawan; Virinder S. Parmar; Ashok K. Prasad; Luciano Saso; Sandra Incerpi; Valentina Pallottini

Book ID
116309384
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
740 KB
Volume
93
Category
Article
ISSN
0300-9084

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## Abstract 3‐Hydroxy 3‐methylglutaryl Coenzyme A reductase (HMG‐CoAR) and its end‐products are crucial for insulin‐induced differentiation of fetal rat myoblasts (L6) both at early and terminal stages of development. Inhibition of HMG‐CoAR activity and reduction of the enzyme levels impair the exp