Short and Efficient Approach Towards Buxozine-C, an Alkaloid from Buxus sempervirens

✍ Scribed by Hai-Feng Liu; Min Ji; Jin Cai

• Publisher: John Wiley and Sons
• Year: 2006
• Tongue: English
• Weight: 219 KB
• Volume: 339
• Category: Article
• ISSN: 0365-6233
• DOI: 10.1002/ardp.200600063

✦ Synopsis

Abstract

Buxus alkaloids display a wide range of interesting pharmacological activities. Here, we present a short and efficient approach towards one of the alkaloids, buxozine‐C. The first synthesis has been achieved with 91% yield starting from cyclovirobuxine‐D by forming a tetrahydro‐oxazine ring with formaldehyde at room temperature.