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Shikonin modulates cell proliferation by inhibiting epidermal growth factor receptor signaling in human epidermoid carcinoma cells

✍ Scribed by Fiza Singh; Dayuan Gao; Mark G Lebwohl; Huachen Wei


Book ID
117467826
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
240 KB
Volume
200
Category
Article
ISSN
0304-3835

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Previous studies have reported that the proliferation of A431 cells, a human squamous cell carcinoma cell line, was stimulated by picomolar epidermal growth factor (EGF) but inhibited by nanomolar EGF. This biphasic dose-response phenomenon is not observed in normal human epithelial cells where nano