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Shared determinants of receptor binding for subtype selective, and dual endothelin-angiotensin antagonists on the AT1 angiotensin II receptor

✍ Scribed by David Dascal; Vaneet Nirula; Kimberly Lawus; Sung-Eun Yoo; Thomas F Walsh; Kathryn Sandberg


Book ID
117108736
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
222 KB
Volume
423
Category
Article
ISSN
0014-5793

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This was a 2-period randomized, crossover study in 8 healthy males to determine the effects of cimetidine (400 mg q.i.d. for 6 days) on the pharmacokinetics and pharmacodynamic effects of the angiotensin II receptor antagonist, losartan (100 mg). Cimetidine increased the AUC for losartan 18% without