๐”– Bobbio Scriptorium
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Shape and accessible surface area of globular proteins

โœ Scribed by Ronald E. Gates


Book ID
118918107
Publisher
Elsevier Science
Year
1979
Tongue
English
Weight
507 KB
Volume
127
Category
Article
ISSN
0022-2836

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Determination of the accessible surface
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Results are presented for proteins with known three-dimensional structure (lysozyme, myoglobin, ribonuclease), which show that the probability of label incorporation upon bombardment by "hot" tritium atoms may be quantitatively linked with the surface area of the protein accessible to water molecule

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Globular proteins fold into compact particles with interior amino acid residues shielded from the surrounding aqueous environment. An early hypothesis holds that entropic hydrophobic forces drive this phenomenon. However, previous analyses based on a binary description of the accessible surfaces of