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SH3GL2 is frequently deleted in non-small cell lung cancer and downregulates tumor growth by modulating EGFR signaling

✍ Scribed by Santanu Dasgupta, Jin Sung Jang, Chunbo Shao…


Book ID
120706199
Publisher
Springer
Year
2012
Tongue
English
Weight
809 KB
Volume
91
Category
Article
ISSN
0946-2716

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## Abstract Identification of a homozygous deletion in cancer cells provides strong evidence for the location of a tumor suppressor gene (TSG). We analyzed the 2p24 homozygous deletion of a non‐small‐cell lung cancer (NSCLC) cell line, NCI‐H2882, and found that the deletion size was 3.7 Mbp. Since